Nucleotide degradation and ribose salvage in yeast
نویسندگان
چکیده
منابع مشابه
Nucleotide degradation and ribose salvage in yeast
Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway. Nutrient starvation, via PKA, AMPK/SNF1, and TOR, triggers autophagic breakdown of ribosomes into nucleotides. A protein not previously associated with nucleotide degradation, Phm8, converts nucleotide monophosphates into nucleosides. Downstream ...
متن کاملNucleotide Salvage Deficiencies, DNA Damage and Neurodegeneration
Nucleotide balance is critically important not only in replicating cells but also in quiescent cells. This is especially true in the nervous system, where there is a high demand for adenosine triphosphate (ATP) produced from mitochondria. Mitochondria are particularly prone to oxidative stress-associated DNA damage because nucleotide imbalance can lead to mitochondrial depletion due to low repl...
متن کاملSynthesis and degradation of poly(ADP-ribose) in plants.
Poly(ADP-ribosylation) is a post-translational modification of proteins involved in a wide range of molecular and cellular processes in mammalian system. The main enzymes responsible for this modification are the poly(ADP-ribose) polymerases that catalyze the transfer of ADP-ribose moieties from NAD + to target protein acceptors, producing long and branched ADP-ribose polymers. The poly(ADP-rib...
متن کاملInfluence of ribose on adenine salvage after intense muscle contractions.
The influence of ribose supplementation on skeletal muscle adenine salvage rates during recovery from intense contractions and subsequent muscle performance was evaluated using an adult rat perfused hindquarter preparation. Three minutes of tetanic contractions (60 tetani/min) decreased ATP content in the calf muscles by approximately 50% and produced an equimolar increase in IMP. Effective rec...
متن کاملCan Yeast Salvage Folate? Bioinformatics Suggests Yes!
Folate is an important nutrient for cell growth and division in all organisms. Many microorganisms including prokaryotes and eukaryotes can synthesize their own folate while humans cannot. To assimilate folate into the cell a folate transporter is required for uptake through the cell membrane. Three types of folate transporters are known to exist in humans to facilitate the uptake of folate: Re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2013
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2013.21